Mast cell fact sheet
Guidance documents
- Glossary of mast cell related terms: A-E
- Glossary of mast cell related terms: F-L
- Glossary of mast cell related terms: M-O
- Glossary of mast cell related terms: P-Z
- How to activate mast cells: Receptor and Ligands Master Table (part 1)
- How to activate mast cells: Receptor and Ligands Master Table (part 2)
- How to activate mast cells: Receptor and Ligands Master Table (part 3)
- How to travel with mast cell disease
- Initial diagnosis and treatment of mast cell activation disease: General notes for guidance
- I think I might have mast cell disease: FAQ
- Language matters: Mast cell terminology
- Mast cell disease fact sheet
- Mast cell medications: Antihistamines by receptor activity
- Master table of de novo mast cell mediators
- Master table of stored mast cell mediators
- MCAD: General information for the public
- MCAD, MCAS and the hierarchy of mast cell disease classifications
- My surgery with mast cell disease pro-tips
- Premedication and surgical concerns in mast cell patients
- Symptoms of mast cell disease
- Symptoms, mediators and mechanisms: A general review (Part 1 of 2)
- Symptoms, mediators and mechanisms: A general review (Part 2 of 2)
- The Devil’s Arithmetic
- The MastAttack 107: The Layperson’s Guide to Understanding Mast Cell Diseases
- The Provider Primer Series
- What do all these words mean? (Part 1)
- What do all these words mean? (Part 2)
Diagnosis
- Bone marrow biopsy
- Diagnosis of mast cell diseases
- Explain the tests: Complete blood count (CBC) with differential and platelets (Part One)
- Explain the tests: Complete blood count (CBC) – Low red cell count (Part two)
- Explain the tests: Complete blood count (CBC) – High red cell count (Part 3)
- Explain the tests: Complete blood count (CBC) – Red cell indices (Part 4)
- In which I answer your questions (Part 1)
- Initial diagnosis and treatment of mast cell activation disease: General notes for guidance
- I think I might have mast cell disease: FAQ
- Language matters: Mast cell terminology
- Mast cell look alikes
- MCAS: Differing criteria among experts
- MCAS and MMAS: Similarities and differences
- MCAD, MCAS and the hierarchy of mast cell disease classifications
- Misdiagnosis in America
- Progression of mast cell diseases (Part 3)
- The difference between CD117+ and CKIT+
Treatment
- Anticholinergic effects of mast cell medications
- Anticholinergic use and dementia
- Antihistamine table: Generics and US brand names
- Anti-inflammatory properties of H1 antihistamines
- Chronic urticaria and angioedema: Part 5
- Epinephrine, anaphylaxis and when to use your Epipen
- Initial diagnosis and treatment of mast cell activation disease: General notes for guidance
- Mast cell medications: Everything but antihistamines
- Mast cell medications: Antihistamines by receptor activity
- MCAS: Treatment
- Naturally occurring mast cell stabilizers: Part 1
- Naturally occurring mast cell stabilizers: Part 2
- Naturally occurring mast cell stabilizers: Part 3
- Naturally occurring mast cell stabilizers: Part 4
- Pharmacology of H1 antihistamines
- Treatment of anaphylaxis
Progression of mast cell diseases
- Progression of mast cell diseases: Part 1
- Progression of mast cell diseases: Part 2
- Progression of mast cell diseases (Part 3)
- Progression of mast cell diseases (Part 4)
- Progression of mast cell diseases (Part 5)
Death from mast cell disease
Symptoms and effects of mast cell disease
- Fragrance allergy
- Mast cell mediators: Prostaglandin D2 (PGD2)
- MCAS: Respiratory symptoms
- Respiratory symptoms
- Sorry not sorry – Why I’m calling out singer Natalie Grant
Eye, ear, nose and mouth symptoms
Neuropsychiatric symptoms
- Anticholinergic use and dementia
- Cognitive effects of mast cell disease
- Depression in mastocytosis patients: A symptom, not a reaction
- Histamine effects on neurotransmitters (serotonin, dopamine and norepinephrine)
- Mast cells in nerve pain
- MCAS: Neurologic and psychiatric symptoms
- Mood disorders and inflammation: Mediators (Part 1 of 4)
- Mood disorders and inflammation: High cortisol and low serotonin (Part 2 of 4)
- Mood disorders and inflammation: Inflammatory conditions and treatment (Part 3 of 4)
- Mood disorders and inflammation: Neurologic effects and treatment (Part 4 of 4)
- Neurologic symptoms of mast cell disease
- Neuropsychiatric features of mast cell disease: Part 1 of 2
- Neuropsychiatric features of mast cell disease: Part 2 of 2
Hematologic Symptoms
Sleep
Anemia
- Anemia of chronic inflammation
- Effect of anemia on mast cells
- Hemolytic anemia
- MCAS: Anemia and deficiencies
Bone symptoms
- Bone involvement in ISM, SSM, SM-AHNMD and ASM: Clarifications (part 1)
- Bone involvement in ISM, SSM, SM-AHNMD and ASM: More literature review (part 2)
- Bone involvement in ISM, SSM, SM-AHNMD and ASM: More literature review (part 3)
- Bone manifestations of SM: Part One
- Bone manifestations of SM: Part Two
- Osteoporosis and fractures in mastocytosis
- Questions on bone involvement
Cardiovascular symptoms
- Blood pressure and mast cell disease
- Cardiovascular manifestations of mast cell disease: Part 1 of 5
- Cardiovascular manifestations of mast cell disease: Part 2 of 5
- Cardiovascular manifestations of mast cell disease: Part 3 of 5
- Cardiovascular manifestations of mast cell disease: Part 4 of 5
- Cardiovascular manifestations of mast cell disease: Part 5 of 5
- In which I answer your questions (Part 1)
- In which I answer your questions (part 2)
- Kounis Syndrome
- Kounis Syndrome: Subtypes and effects of mast cell mediators (Part 1 of 4)
- Kounis Syndrome: Diagnosis (Part 2 of 4)
- Kounis Syndrome: Treatment (Part 3 of 4)
- Kounis Syndrome: Stress (Part 4 of 4)
- Mast cells and cardiac and vascular dysfunction
- Mast cells and metabolic syndrome: Hypertension, obesity and atherosclerosis
- Mast cells in vascular disease: Part 1
- Mast cells in vascular disease: Part 2
- Mast cells in vascular disease: Part 3
- Third spacing
Metabolic and endocrinology symptoms
- Corticotropin releasing hormone, cortisol and mast cells
- Diabetes, mast cells and allergic disease
- Diabetes, steroids and hypoglycemia
- Effect of vitamin D on mast cells
- Effects of estrogen and progesterone and the role of mast cells in pregnancy
- Interplay between mast cells and hormones: Part 1 of 8
- Interplay between mast cells and hormones: Part 2 of 8
- Leptin: the obesity hormone released by mast cells
- Mast cells and metabolic syndrome: Hypertension, obesity and atherosclerosis
- Metabolic issues associated with MCAS
- The effects of cortisol on mast cells: Cortisol and HPA Axis (Part 1 of 3)
- The effects of cortisol on mast cells: Part 2 of 3
- The effects of cortisol on mast cells: Part 3 of 3
Genitourinary symptoms
- Effects of estrogen and progesterone and the role of mast cells in pregnancy
- Mast cells in kidney disease
- MCAS: Kidney, urinary and genital concerns
Sex
- Sex and chronic illness
- Sex and chronic illness series: vaginal pain
- The Sex Series – Part One: Kissing and allergic reactions
- The Sex Series – Part Two: Contact dermatitis
- The Sex Series – Part Three: Allergic reactions of the vagina and vulva
- The Sex Series – Part Four: Seminal allergy
- The Sex Series – Part Five: Seminal allergy, post-orgasmic illness syndrome and burning semen syndrome
- The Sex Series – Part Six: Male pelvic dysfunction and mast cells
- The Sex Series – Part Seven: Mast cell activation and anal penetration
- The Sex Series – Part Eight: Female pelvic floor dysfunction (1 of 2)
- The Sex Series – Part Nine: Female pelvic floor dysfunction (2 of 2)
Pregnancy
- Effects of estrogen and progesterone and the role of mast cells in pregnancy
- In which I answer your questions (Part 2)
- Pregnancy in mastocytosis
Kidney symptoms
Constitutional symptoms
Gastrointestinal symptoms
- Gastrointestinal manifestations of SM: Part 1
- Gastrointestinal manifestations of SM: Part 2
- Mast cells in the GI tract: How many is too many? (Part One)
- Mast cells in the GI tract: How many is too many? (Part Two)
- Mast cells in the GI tract: How many is too many? (Part Three)
- Mast cells in the GI tract: How many is too many? (Part Four)
- Mast cells in the GI tract: How many is too many? (Part Five)
- Mast cells in the GI tract: How many is too many? (Part Six)
- Mast cells in the GI tract: How many is too many? (Part Seven)
- Mast cells in the GI tract: How many is too many? (Part Eight)
- Mastocytic enterocolitis
- MCAS: GI Symptoms and Liver Abnormalities
- No solids, clear liquids and NPO
Mastocytic enterocolitis
- Mast cells in the GI tract: How many is too many? (Part One)
- Mast cells in the GI tract: How many is too many? (Part Two)
- Mast cells in the GI tract: How many is too many? (Part Three)
- Mast cells in the GI tract: How many is too many? (Part Four)
- Mast cells in the GI tract: How many is too many? (Part Five)
- Mast cells in the GI tract: How many is too many? (Part Six)
- Mast cells in the GI tract: How many is too many? (Part Seven)
- Mast cells in the GI tract: How many is too many? (Part Eight)
- Mastocytic enterocolitis
Scent reactions
Pain
Spleen
Exercise intolerance
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 1
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 2
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 3
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 4
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 5
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 6
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 7
- Exercise and mast cell activity
- Histamine depletion in exercise
- My exercise program for POTS and deconditioning
Mast cell attacks and anaphylaxis
Mast cell attacks
- Anaphylaxis and mast cell reactions
- How to get out of a reaction cycle
- Stopping mast cell attacks with medication, and when you need to use epi
Anaphylaxis
- Anaphylaxis and mast cell reactions
- Biphasic anaphylaxis
- Effects of Platelet Activating Factor (PAF) in asthma and anaphylaxis
- Epinephrine, anaphylaxis and when to use your Epipen
- How to recognize anaphylaxis
- IgE-independent anaphylaxis
- Stopping mast cell attacks with medication, and when you need to use epi
- The definition of anaphylaxis
- Treatment of anaphylaxis
Surgery and emergency care
Surgery and procedures
- Bone marrow biopsy
- My surgery with mast cell disease pro-tips
- Premedication and surgical concerns in mast cell patients
Emergency care
Mast cell mediators
Mast cell mediators
- Effect of mast cell mediators on sleep
- Histamine: Intended functions and mast cell symptoms
- Leptin: the obesity hormone released by mast cells
- Lesser known mast cell mediators (Part 1)
- Lesser known mast cell mediators (Part 2)
- Lesser known mast cell mediators (Part 3)
- Lesser known mast cell mediators (Part 4)
- Lesser known mast cell mediators (Part 5)
- Lesser known mast cell mediators (Part 6)
- Mast cell mediator release mechanisms
- Mast cell mediators: Prostaglandin D2 (PGD2)
- Mast cell mediators: Recommended testing for MCAS diagnosis
- Mast cell mediators: Sphingosine-1-phosphate
- Mast cells and cardiac and vascular dysfunction
- Mast cells, heparin and bradykinin: The effects of mast cells on the kinin-kallikrein system
- Mast cells in vascular disease: Part 1
- Mast cells in vascular disease: Part 2
- Mast cells in vascular disease: Part 3
- Master table of de novo mast cell mediators
- Master table of stored mast cell mediators
- MCAS: Neurologic and psychiatric symptoms
- Prostaglandin E2, mast cells and asthma
- Prostaglandins and leukotrienes
- Symptoms, mediators and mechanisms: A general review (Part 1 of 2)
- Symptoms, mediators and mechanisms: A general review (Part 2 of 2)
Bradykinin
- Chronic urticaria and angioedema: Part 3
- Chronic urticaria and angioedema: Part 4
- Mast cells, heparin and bradykinin: The effects of mast cells on the kinin-kallikrein system
Histamine
- Anti-inflammatory properties of H1 antihistamines
- Histamine effects on neurotransmitters (serotonin, dopamine and norepinephrine)
- Histamine: Intended functions and mast cell symptoms
- Mast cell medications: Antihistamines by receptor activity
- Mast cells and cardiac and vascular dysfunction
- Pharmacology of H1 antihistamines
Prostaglandin D2
- Exercise and mast cell activity
- Mast cell mediators: Prostaglandin D2 (PGD2)
- MCAS: Neurologic and psychiatric symptoms
Platelet Activating Factor
Tryptase
- Patient questions: Everything you wanted to know about tryptase?
- Patient questions: Why isn’t tryptase used to track SM progression in patients with SM-AHNMD?
Genetics and heritability of mast cell disease
Genetics of mast cell disease
- DNA Methylation: How it works
- Gene expression and the D816V mutation
- Genetics of MCAS: Mutations and methylation
- Heritable mutations in mastocytosis
- Mast cell disease in families
- Mast cell mutations: JAK2 and myeloproliferative neoplasms
- Mast cell mutations: TET2 and mutation profiles of aggressive subtypes
- Mast cell mutations: SRSF2 in SM-AHNMD
Mast cell biology
- Allergic effector unit: The interactions between mast cells and eosinophils
- Allergic to infections: Other behaviors of toll like receptors
- Allergic to infections: How bacteria, viruses and fungi activate mast cells
- Circadian rhythm of mast cells
- Clinically significant causes of mast cell activation
- Diabetes, mast cells and allergic disease
- Diabetes, steroids and hypoglycemia
- How to activate mast cells: Complement protein C3a
- How to activate mast cells: Receptor and Ligands Master Table (part 1)
- How to activate mast cells: Receptor and Ligands Master Table (part 2)
- How to activate mast cells: Receptor and Ligands Master Table (part 3)
- Immunoglobulin free light chains: A possible link between autoimmune disease and mast cell activation
- Kounis Syndrome
- Life and death of mast cells
- Mast cell inhibitory effects of some microorganisms
- Mast cell interactions: B and T cells
- Mast cell mediator release mechanisms
- Mast cells and cardiac and vascular dysfunction
- Mast cells, eosinophils and the perfect storm of inflammation
- Mast cells in vascular disease: Part 1
- Mast cells in vascular disease: Part 2
- Mast cells in vascular disease: Part 3
- Mast cells in wound healing
- Regulation of mast cells by IgE and stem cell factor (SCF)
- The difference between CD117+ and CKIT+
Associated Conditions
Dysautonomia (POTS
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 1
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 2
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 3
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 4
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 5
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 6
- Deconditioning, orthostatic intolerance, exercise and chronic illness – Part 7
- Hypermobility Type Ehlers Danlos Syndrome and Autonomic Dysfunction (Part One)
- Hypermobility Type Ehlers Danlos Syndrome and Autonomic Dysfunction (Part Two)
- Hypermobility Type Ehlers Danlos Syndrome and Autonomic Dysfunction (Part Three)
- Hypermobility Type Ehlers Danlos Syndrome and Autonomic Dysfunction (Part Four)
- Hypermobility Type Ehlers Danlos Syndrome and Autonomic Dysfunction (Part Five)
- My exercise program for POTS and deconditioning
- POTS (Postural Orthostatic Tachycardia Syndrome)
Asthma
- Circadian rhythm of mast cells
- Effects of Platelet Activating Factor (PAF) in asthma and anaphylaxis
- Exercise and mast cell activity
- Fragrance allergy
- Histamine depletion in exercise
- Prostaglandin E2, mast cells and asthma
Urticaria and angioedema
- Activating the complement system: Classical, alternative and lectin pathways
- Angioedema: Part 1
- Angioedema: Part 2
- Angioedema: Part 3
- Angioedema: Part 4
- Chronic urticaria and angioedema: Part 1
- Chronic urticaria and angioedema: Part 2
- Chronic urticaria and angioedema: Part 3
- Chronic urticaria and angioedema: Part 4
- Chronic urticaria and angioedema: Part 5
- Role of sex hormones in hereditary angioedema
Gastroparesis
- Gastroparesis: Part 1
- Gastroparesis: Treatment (part 2)
- Gastroparesis: Diabetes and gastroparesis (Part Three)
- Gastroparesis: Post-surgical gastroparesis (Part Four)
- Gastroparesis: Less common causes (Part Five)
- Gastroparesis: Autonomic nervous system and vagus nerve (Part Six)
- Gastroparesis: Idiopathic gastroparesis (Part Seven)
Ehlers Danlos Syndrome
- Ehlers-Danlos Syndrome (EDS)
- Hypermobility Type Ehlers Danlos Syndrome and Autonomic Dysfunction (Part One)
- Hypermobility Type Ehlers Danlos Syndrome and Autonomic Dysfunction (Part Two)
- Hypermobility Type Ehlers Danlos Syndrome and Autonomic Dysfunction (Part Three)
- Hypermobility Type Ehlers Danlos Syndrome and Autonomic Dysfunction (Part Four)
- Hypermobility Type Ehlers Danlos Syndrome and Autonomic Dysfunction (Part Five)
Associated conditions
Lyme Disease
- Lyme disease: Disease staging and typical treatment recommendations (Part 1)
- Lyme disease: CDC Recommended Diagnostics (Part 2)
- Lyme disease: Chronic Lyme (part 3)
- Lyme disease: Chronic Lyme (part 4)
- Lyme disease: Chronic Lyme (part 5)
- Lyme disease: Chronic Lyme (part 6)
- Lyme disease: Chronic Lyme (part 7)
- Lyme disease: Coinfections (part 8)
- Lyme disease: IDSA, ILADS and my conclusions (Part 9)
Allergies
Myeloproliferative neoplasms
- Mast cell mutations: JAK2 and myeloproliferative neoplasms
- Myelodysplastic syndrome (MDS)
- The question I get asked the most
Autoimmune disease
- Immunoglobulin free light chains: A possible link between autoimmune disease and mast cell activation
- Role of mast cells in autoimmune diseases
Food allergies
- Food allergy series: Atopy, risk factors and frequency
- Food allergy series: Eosinophilic colitis
- Food allergy series: Eosinophilic esophagitis (Part 1)
- Food allergy series: Eosinophilic esophagitis (Part 2)
- Food allergy series: Eosinophilic esophagitis (Part 3)
- Food allergy series: Eosinophilic gastrointestinal disease (Part 1)
- Food allergy series: Eosinophilic gastrointestinal disease (Part 2)
- Food allergy series: Eosinophilic gastrointestinal disease (Part 3)
- Food allergy series: Food related allergic disorders
- Food allergy series: FPIES (part 1)
- Food allergy series: FPIES (part 2)
- Food allergy series: Mast cell food reactions and the low histamine diet
- Food allergy series: Risk factors for developing food allergies
- Inconvenient: The reality of living with food allergies
Low histamine diet
- Food allergy series: Mast cell food reactions and the low histamine diet
- How to eat low histamine if you’re me
- Not a cure
FPIES
Eosinophilic disease
- Allergic effector unit: The interactions between mast cells and eosinophils
- Eosinophilic esophagitis
- Food allergy series: Eosinophilic colitis
- Food allergy series: Eosinophilic esophagitis (Part 1)
- Food allergy series: Eosinophilic esophagitis (Part 2)
- Food allergy series: Eosinophilic esophagitis (Part 3)
- Food allergy series: Eosinophilic gastrointestinal disease (Part 1)
- Food allergy series: Eosinophilic gastrointestinal disease (Part 2)
- Food allergy series: Eosinophilic gastrointestinal disease (Part 3)
- Food allergy series: Food related allergic disorders
- Mast cells, eosinophils and the perfect storm of inflammation
Disability and Rare Diseases
Disability
Rare Diseases
Realities of chronic illness
- Chronic illness and work
- Cost of US Healthcare
- Event zero
- Kvetching circles; or, How to support your favorite sick person and the people in their lives
- Medical bankruptcy
- PTSD and Medical Trauma
- Societal expectations of the sick
- The doctor-patient relationship and the danger of self-advocating
Miscellaneous
Antibiotic resistance
Central lines
- Becoming reality
- Do all mast cell patients need central lines? No. But some do.
- PICC Lines
- PICC Lines: Dressing change and blood draw
- PICC Lines: Nomenclature, fluid infusions and IV Benadryl
- This is what being sick looks like
Clinical trials
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